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Most importantly, unlike other opioids, tramadol doesn’t have any clinically important effects on cardiovascular or respiratory parameters. Tramadol may prove especially beneficial in patients who have poor cardiopulmonary function, including the elderly, the obese and smokers, in patients with impaired hepatic or renal function, in addition to in patients in whom nonsteroidal anti-inflammatory prescription medication is not suggested or should be in combination with caution. Parenteral or oral tramadol has been shown to be a powerful and well tolerated analgesic agent inside the perioperative setting.
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